Golden Gopher Magnetic Biosensing

Technology Invovation

Z-Lab is a magnetic biosensing system that has detected biomarkers in unprocessed human serum and urine, heavy metals like mercury (2+) in lake water. Ultra high sensitivity (up to 200 molecules per magnetic sensor) has been demonstrated. The Golden Gopher Magnetic Biosensing Team has also begun to develop z-Lab 2.0 and z-Lab 3.0, which are smaller, more versatile, and more portable versions of z-Lab.

Team Story

Researchers from the University of Minnesota, Mayo Clinic, and several companies – a GMR biosensing start-up company (Zepto Life Technology LLC), a start-up company which fabricates magnetic nanoparticles (Universal Magnetic System LLC), a large biological and assay development company (R&D Systems), an audio electronics repair company (Jim Sawyer Professional Audio Service), and a mechanical design company (Vates) – teamed up to form the Golden Gopher Magnetic Biosensing Team. Inspired by Dr. Jian-Ping Wang's vision of a low-cost, easy-to-use, accurate, portable GMR biosensing system, they have contributed their areas of expertise to build z-Lab and begin to design and construct z-Lab 2.0 and z-Lab 3.0.

About Our Team Leader

Jian-Ping Wang is an electrical and magnetic materials engineer with research expertise in magnetic and spintronic devices and materials. His independent research has focused on developing nanomagnetic and spintronic devices and fabricating and understanding novel magnetic materials for information technology and biomedical applications. Over the past twelve years, Dr. Wang has established a dynamic magnetic biosensing research laboratory at the University of Minnesota, which led to the formation of this Golden Gopher Magnetic biosensing team. Dr. Wang is a Distinguished McKnight University Professor of Electrical and Computer Engineering and a member of the graduate faculty in Physics, Chemical Engineering and Materials Science and Biomedical Engineering at the University of Minnesota. He is also the director of the Center for Spintronic Materials, Interfaces and Novel Architectures (C-SPIN). He has authored and co-authored more than six book chapters, 210 publications in peer-reviewed top journals and conference proceedings, and he also holds three dozen patents and applications. He and his students have co-founded three startup companies based on the technologies developed in his research laboratory.

Selected Publications

Srinivasan, B., Li, Y., Jing, Y., Xu, Y., Yao, X., Xing, C., & Wang, J.-P. (2009). A detection system based on giant magnetoresistive sensors and high-moment magnetic nanoparticles demonstrates zeptomole sensitivity: potential for personalized medicine. Angewandte Chemie (International Ed. in English), 48(15), 2764–7. DOI: 10.1002/anie.200806266

Li, Y., Srinivasan, B., Jing, Y., Yao, X., Hugger, M. a, Wang, J.-P., & Xing, C. (2010). Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera. Journal of the American Chemical Society, 132(12), 4388–92. DOI: 10.1021/ja910406a

Srinivasan, B., Li, Y., Jing, Y., Xing, C., Slaton, J., & Wang, J. P. (2011). A three-layer competition-based giant magnetoresistive assay for direct quantification of endoglin from human urine. Analytical chemistry, 83(8), 2996-3002. DOI: 10.1021/ac2005229

Wang, W., Wang, Y., Tu, L., Klein, T., Feng, Y., Li, Q., & Wang, J.-P. (2014). Magnetic detection of mercuric ion using giant magnetoresistance-based biosensing system. Analytical Chemistry, 86(8), 3712–6. DOI: 10.1021/ac404015j

Wang, W., Wang, Y., Tu, L., Klein, T., Feng, Y., & Wang, J. P. (2013). Surface Modification for Protein and DNA Immobilization onto GMR Biosensor. Magnetics, IEEE Transactions on, 49(1), 296-299. DOI: 10.1109/TMAG.2012.2224327

Klein, T., Wang, Y., Tu, L., Yu, L., Feng, Y., Wang, W., & Wang, J. P. (2014). Comparative analysis of several GMR strip sensor configurations for biological applications. Sensors and Actuators A: Physical, 216, 349-354. DOI: 10.1016/j.sna.2014.05.033

Wang, W., Wang, Y., Tu, L., Feng, Y., Klein, T., & Wang, J. P. (2014). Magnetoresistive performance and comparison of supermagnetic nanoparticles on giant magnetoresistive sensor-based detection system. Scientific reports, 4. DOI: 10.1038/srep05716

Wang, W., Jing, Y., He, S., Wang, J. P., & Zhai, J. P. (2014). Surface modification and bioconjugation of FeCo magnetic nanoparticles with proteins. Colloids and Surfaces B: Biointerfaces, 117, 449-456. DOI: 10.1016/j.colsurfb.2013.11.050

Wang, W., He, S., Jing, Y., Yu, L., Wang, J. P., & Zhai, J. P. (2013). Immobilization of DNA on Fe nanoparticles and their hybridization to functionalized surface. Journal of nanoparticle research, 15(6), 1-10. DOI: 10.1007/s11051-013-1722-2

Patra, C. R., Jing, Y., Xu, Y. H., Bhattacharya, R., Mukhopadhyay, D., Glockner, J. F., ... & Mukherjee, P. (2010). A core-shell nanomaterial with endogenous therapeutic and diagnostic functions. Cancer nanotechnology, 1(1-6), 13-18. DOI: 10.1007/s12645-010-0002-4

Bai, J., Xu, Y. H., & Wang, J. P. (2007). Cubic and spherical high-moment FeCo nanoparticles with narrow size distribution. Magnetics, IEEE Transactions on, 43(7), 3340-3342. DOI: 10.1109/TMAG.2007.893781